DevS, a Heme-Containing Two-Component Oxygen Sensor of Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Two-Component System of Mycobacterium Tuberculosis
Two Component Systems (TCSs), are widespread signal transduction devices in prokaryotes that enable these organisms to elicit an adaptive response to environmental stimuli, primarily through changes in gene expression [1]. They are typically composed of a membrane-located sensor with histidine kinase activity and a cytoplasmic transcriptional regulator. Generally, stimuli detected by TCS autoph...
متن کاملDesign and Construction of a Cloning Vector Containing the hspX Gene of Mycobacterium tuberculosis
Background: Tuberculosis (TB) is a major cause of death worldwide. Finding an effective vaccine against TB is the best way to control it. Several vaccines against this disease have been developed but none are completely protective. The aim of this study was to design and construct a cloning vector containing the Mycobacterium tuberculosis (M. tuberculosis) heat shock protein X (hspX). Metho...
متن کاملA STUDY OF MYCOBACTERIUM TUBERCULOSIS DRUG RESISTANCE IN PULMONARY TUBERCULOSIS
Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...
متن کاملAn essential two-component signal transduction system in Mycobacterium tuberculosis.
The bacterial two-component signal transduction systems regulate adaptation processes and are likely to play a role in Mycobacterium tuberculosis physiology and pathogenesis. The previous initial characterization of an M. tuberculosis response regulator from one of these systems, mtrA-mtrB, suggested its transcriptional activation during infection of phagocytic cells. In this work, we further c...
متن کاملInhibition of the DevSR Two-Component System by Overexpression of Mycobacterium tuberculosis PknB in Mycobacterium smegmatis
The DevSR (DosSR) two-component system, which is a major regulatory system involved in oxygen sensing in mycobacteria, plays an important role in hypoxic induction of many genes in mycobacteria. We demonstrated that overexpression of the kinase domain of Mycobacterium tuberculosis (Mtb) PknB inhibited transcriptional activity of the DevR response regulator in Mycobacterium smegmatis and that th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemistry
سال: 2007
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi602422p